Intra-articular primatised anti-CD4: eYcacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology
نویسندگان
چکیده
Objectives—CD4+ T cells sustain the chronic synovial inflammatory response in rheumatoid arthritis (RA). SB210396/CE 9.1 is an anti-CD4 monoclonal antibody that has documented eYcacy in RA when given intravenously. This study aimed to establish the safety and eYcacy of the intra-articular administration of SB-210396/CE 9.1 compared with placebo, examining its mode of action using a combined imaging approach of arthroscopy, magnetic resonance imaging (MRI), and
منابع مشابه
Intra-articular primatised anti-CD4: efficacy in resistant rheumatoid knees. A study of combined arthroscopy, magnetic resonance imaging, and histology.
OBJECTIVES CD4+ T cells sustain the chronic synovial inflammatory response in rheumatoid arthritis (RA). SB-210396/CE 9.1 is an anti-CD4 monoclonal antibody that has documented efficacy in RA when given intravenously. This study aimed to establish the safety and efficacy of the intra-articular administration of SB-210396/CE 9.1 compared with placebo, examining its mode of action using a combine...
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